University of Nottingham

The closed-loop approach

The EPSRC-funded Cyclops (Closed Loop Control Systems for Optimising Treatment) network is exploring the potential for the closed loop control approach to provide optimised treatment that is personal to the individual patient. This can significantly improve patient outcomes across a range of medical conditions.


Closed loop photo


What are closed loop control systems?

The closed loop control approach involves continuously monitoring key clinical parameters and, informed by mathematical models, adapting treatment.

The advent of masive computer power, highly sensitive, specific and flexible sensors, and finely-titrable treatments has finally allowed closed loop control systems to offer a revolutionary leap in medical treatment.


Challenges that might now be met include:

  • the delivery of  treatment to cancer patients

  • the moment-to-moment management of critically ill (or injured) patients

  • the accelerated healing of chronic wounds

Our plans for the network

We are creating a multidisciplinary team comprising academics, clinicians and industrialists, supported by stakeholders, to address the challenges of the closed-loop approach.

we will hold a series of grand workhops and discussion events and years 1 and 2 that will bring together the community. The aim of the workshops will be to identify gaps in technology or knowledge, which will be addressed by feasibility studies or secondments.

The feasibility studies will run, with further networking between the stakeholders, to provide proof of concept data for grand challenge funding applications. These larger funding applications will be developed in parallel to the feasibility studies.

Feasibility studies

The feasibility studies to explore the closed loop approach will be included here once the first studies are funded.


Room 811, Tower Building, University Park, Nottingham, NG7 2RD. Tel: 0115 74 86695